Mega-Director Joel Schumacher has indicated he would like a go at directing an adaptation of Neil Gaiman's Sandman.
One online site suggested that trying to turn a seventy-five issue opus into a two-hour film is almost an impossible task. So I would suggest only shooting the first story arc and leaving the rest for the sequels, like any comic adaptation. Issue 50 could be a film on it's own.
Last year during the San Diego Comic Con, Neil Gaiman told his fans, "I'd rather no Sandman movie got made than [to have] a bad Sandman movie."